Myelin basic protein (MBP) is a 304-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02686.
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The mean pLDDT of this model is 54.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 51% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of…
Homodimer. Isoform 3 exists as a homodimer
Myelin membrane, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1FV1 | X-ray | 1.9 Å | C/F=218-237 |
| 1K2D | X-ray | 2.2 Å | P=134-144 |
| 1BX2 | X-ray | 2.6 Å | C/F=217-231 |
| 1ZGL | X-ray | 2.8 Å | C/F/I/L=221-233 |
| 1HQR | X-ray | 3.2 Å | C=221-233 |
| 1YMM | X-ray | 3.5 Å | C=217-242 |
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