Osteocalcin (BGLAP) is a 100-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02818.
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The mean pLDDT of this model is 76.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 40% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:3019668, PubMed:6967872). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (PubMed:6967872, PubMed:39880952)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8XS1 | X-ray | 2.3 Å | A=94-100 |
| 9L23 | EM | 2.62 Å | B=33-100 |
| 9WF2 | EM | 2.94 Å | B=33-100 |
| 9BUR | EM | 2.95 Å | B=1-100 |
| 9BUX | EM | 3.06 Å | B=1-100 |
| 9MQC | EM | 3.13 Å | P=1-100 |
| 9MQB | EM | 3.37 Å | P=1-100 |
| 9MQE | EM | 3.56 Å | P=1-100 |
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