Glycoprotein 42 (BZLF2) is a 223-residue protein from Epstein-Barr virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P03205.
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The mean pLDDT of this model is 79.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor-class II-peptide interaction
Forms a complex with gp25 and gp85 via its N-terminus; this complex is used for invasion of B-lymphocytes. Interacts with human HLA-DRA and HLA-DRB1
Virion membrane, Host membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FD4 | X-ray | 2.4 Å | A/B=33-223 |
| 8TOO | X-ray | 2.6 Å | I/J/K/L=85-223 |
| 1KG0 | X-ray | 2.65 Å | C=86-221 |
| 5W0K | X-ray | 3.1 Å | X/Y=47-81 |
| 8TNT | X-ray | 3.15 Å | C=33-223 |
| 8TNN | X-ray | 3.36 Å | C/F=33-223 |
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