Envelope glycoprotein L (gL) is a 137-residue protein from Epstein-Barr virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P03212.
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The mean pLDDT of this model is 66.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 43% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry
Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. The heterodimer gH/gL interacts with host EPHA2 to facilitate virus internalization and fusion
Virion membrane, Host cell membrane, Host Golgi apparatus, host trans-Golgi network
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7CZE | X-ray | 3.0 Å | B/D/F/H=24-132 |
| 7S1B | X-ray | 3.03 Å | B=24-137 |
| 5T1D | X-ray | 3.1 Å | B=24-135 |
| 5W0K | X-ray | 3.1 Å | B/D=24-137 |
| 8TNT | X-ray | 3.15 Å | B=24-135 |
| 7S07 | X-ray | 3.29 Å | B=27-124 |
| 8TNN | X-ray | 3.36 Å | B/E=24-135 |
| 7YP1 | EM | 3.54 Å | B=40-127 |
| 3PHF | X-ray | 3.58 Å | 2/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z=24-131 |
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