Medium-wave-sensitive opsin 1 (OPN1MW) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04001.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to medium-wavelength (green) light, thereby stimulating the G(t)/transducin protein pathway (PubMed:2937147, PubMed:6140680). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels (By similarity). The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green…
Monomer. Homodimer. Homotetramer
Cell membrane, Photoreceptor outer segment membrane
Compare the prediction with experimentally determined structures of the same protein:
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