Plasma protease C1 inhibitor (SERPING1) is a 500-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05155.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Serine protease inhibitor, which acrs as a regulator of the classical complement pathway (PubMed:10946292, PubMed:11527969, PubMed:3458172, PubMed:6416294). Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases (PubMed:10946292, PubMed:3458172, PubMed:6416294). May also regulate blood coagulation, fibrinolysis and the generation of kinins (PubMed:8495195). Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein (PubMed:8495195)
Interacts with MASP1
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DU3 | X-ray | 2.1 Å | A/B=119-500 |
| 2OAY | X-ray | 2.35 Å | A=119-500 |
| 5DUQ | X-ray | 2.9 Å | A/B=118-500 |
| 7AKV | EM | 3.6 Å | A=98-500 |
| 8W18 | X-ray | 3.94 Å | I=111-500 |
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