Omega-conotoxin MVIIA is a 71-residue protein from Conus magus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05484.
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The mean pLDDT of this model is 70.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks Cav2.2/CACNA1B calcium channels (IC(50)=0.67-208 nM) (PubMed:26344359, PubMed:34589389, PubMed:7826361). It acts by neutralizing the outer electronegativity and sterically hindering the ion access path to the entrance of the channel selectivity filter (PubMed:34234349). It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361). In vivo, is lethal to fish (PubMed:26344359, PubMed:34589389). In vivo, injection into mammals induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MIX | EM | 3.0 Å | B=46-70 |
| 7VFU | EM | 3.0 Å | E=46-70 |
| 1DW4 | NMR | A=46-70 | |
| 1DW5 | NMR | A=46-70 | |
| 1FEO | NMR | A=46-70 | |
| 1MVI | NMR | A=46-70 | |
| 1OMG | NMR | A=46-70 | |
| 1TT3 | NMR | A=46-70 | |
| 1TTK | NMR | A=46-70 |
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