Neuromodulin (Gap43) is a 227-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06837.
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The mean pLDDT of this model is 56.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 45% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (PubMed:11433297). Interacts (via IQ domain) with calmodulin (PubMed:18493953). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity)
Cell membrane, Cell projection, growth cone membrane, Synapse, Cell projection, filopodium membrane, Perikaryon, Cell projection, dendrite, Cell projection, axon, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4E53 | X-ray | 2.69 Å | A/B=34-57 |
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