Corticoliberin (CRH) is a 196-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06850.
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The mean pLDDT of this model is 62.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Hormone that plays a central role in whole body adaptation to stress (By similarity). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (PubMed:18801728, PubMed:3003585, PubMed:32004469). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3EHU | X-ray | 1.96 Å | C/D=175-194 |
| 6P9X | EM | 2.91 Å | P=154-194 |
| 3EHT | X-ray | 3.4 Å | B=180-194 |
| 1GO9 | NMR | A=154-194 | |
| 1GOE | NMR | A=154-194 |
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