Tyrosine 3-monooxygenase (TH) is a 528-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07101.
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The mean pLDDT of this model is 80.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity)
Homotetramer (PubMed:24947669, Ref.18). Interacts (when phosphorylated at Ser-19) with YWHAG; one YWHAG dimer binds to one TH tetramer and this interaction may influence the phosphorylation and dephosphorylation of other sites (PubMed:24947669). Interacts with NT5DC2; the interaction results in reduced phosphorylation and decreased catalytic activity of TH (By similarity)
Cytoplasm, perinuclear region, Nucleus, Cell projection, axon, Cytoplasm, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2XSN | X-ray | 2.68 Å | A/B/C/D=193-528 |
| 4J6S | X-ray | 3.08 Å | E/F/G/H=1-74 |
| 6ZZU | EM | 3.5 Å | A/B/C/D=194-528 |
| 6ZVP | EM | 4.0 Å | A/B/C/D=71-528 |
| 7A2G | EM | 4.1 Å | A/B/C/D=109-528 |
| 6ZN2 | EM | 4.3 Å | A/C/E/G=194-528, B/D/F/H=71-88 |
| 7PIM | EM | 4.6 Å | A/B/D/F=194-528, C/E/G/H=71-88 |
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