Collagen alpha-2(I) chain (COL1A2) is a 1366-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08123.
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The mean pLDDT of this model is 53.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Type I collagen is a member of group I collagen (fibrillar forming collagen)
Trimers of one alpha 2(I) and two alpha 1(I) chains (Probable). Interacts (via C-terminus) with TMEM131 (via PapD-L domain); the interaction is direct and is involved in assembly and TRAPPIII ER-to-Golgi transport complex-dependent secretion of collagen (PubMed:32095531)
Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CTD | X-ray | 1.6 Å | B=485-495 |
| 8YV3 | X-ray | 1.68 Å | B/C/E/F=992-1021 |
| 5CTI | X-ray | 1.9 Å | B=484-495 |
| 6JEC | X-ray | 2.05 Å | A/B/C=45-72 |
| 5CVA | X-ray | 2.1 Å | A/D=484-495 |
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