ATP-dependent translocase ABCB1 (ABCB1) is a 1280-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08183.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Translocates phospholipids and drugs across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone…
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1
Cell membrane, Apical cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8Y6H | EM | 2.49 Å | A=1-1280 |
| 8Y6I | EM | 2.54 Å | A=1-1280 |
| 7A69 | EM | 3.2 Å | A=1-1280 |
| 6C0V | EM | 3.4 Å | A=1-1280 |
| 9CTG | EM | 3.4 Å | A=1-1280 |
| 7A6F | EM | 3.5 Å | A=1-1280 |
| 7O9W | EM | 3.5 Å | A=1-1280 |
| 6FN1 | EM | 3.58 Å | A=32-1279 |
| 6QEX | EM | 3.6 Å | A=1-1280 |
| 7A6C | EM | 3.6 Å | A=1-1280 |
| 7A6E | EM | 3.6 Å | A=1-1280 |
| 9CTC | EM | 3.6 Å | A=1-1280 |
| 9CR8 | EM | 3.8 Å | A=1-1280 |
| 7A65 | EM | 3.9 Å | A=1-1280 |
| 8SB8 | EM | 3.9 Å | A=1-1280 |
| 8SBA | EM | 3.9 Å | A=1-1280 |
| 9CTF | EM | 3.9 Å | A=1-1280 |
| 8SB7 | EM | 4.0 Å | A=1-1280 |
| 8SA0 | EM | 4.1 Å | A=1-1274 |
| 8SB9 | EM | 4.1 Å | A=1-1280 |
Showing 20 of 24 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.