Integrin alpha-5 (ITGA5) is a 1049-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08648.
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The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for…
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. ITGA5/Alpha-5 associates with ITGB1/beta-1 (PubMed:33962943). Interacts with NISCH (PubMed:11912194). Interacts with HPS5 (PubMed:10094488). Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1…
Cell membrane, Cell junction, focal adhesion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4WK0 | X-ray | 1.78 Å | A=42-493 |
| 4WJK | X-ray | 1.85 Å | A=42-493 |
| 4WK2 | X-ray | 2.5 Å | A=42-493 |
| 4WK4 | X-ray | 2.5 Å | A=42-491 |
| 9B9J | EM | 2.6 Å | A=1-995 |
| 9P6S | EM | 2.61 Å | A=42-642 |
| 9B9K | EM | 2.7 Å | A=1-995 |
| 3VI3 | X-ray | 2.9 Å | A/C=42-664 |
| 3VI4 | X-ray | 2.9 Å | A/C=42-664 |
| 9DIA | EM | 2.97 Å | A=1-996 |
| 7NWL | EM | 3.1 Å | A=42-1049 |
| 9CKV | EM | 3.19 Å | A=1-996 |
| 9EF2 | EM | 3.36 Å | A=1-996 |
| 7NXD | EM | 4.6 Å | A=42-1049 |
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