5-hydroxytryptamine receptor 1A (HTR1A) is a 422-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08908.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:8138923, PubMed:8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and…
Heterodimer; heterodimerizes with GPER1 (PubMed:23300088). Interacts with YIF1B (By similarity). Interacts with GPR39 and GALR1 (PubMed:26365466)
Cell membrane, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9HYI | EM | 2.3 Å | R=1-422 |
| 8PJK | EM | 2.4 Å | R=1-422 |
| 9VJE | EM | 2.47 Å | R=25-422 |
| 9KVI | EM | 2.54 Å | R=25-422 |
| 9KVH | EM | 2.59 Å | R=25-422 |
| 8FYX | EM | 2.62 Å | R=26-422 |
| 9VJ6 | EM | 2.62 Å | R=25-422 |
| 9KVG | EM | 2.63 Å | R=25-422 |
| 8FYT | EM | 2.64 Å | R=26-422 |
| 9VJG | EM | 2.67 Å | R=25-422 |
| 9VJ5 | EM | 2.69 Å | R=25-422 |
| 9VJF | EM | 2.7 Å | R=25-422 |
| 9DYF | EM | 2.74 Å | R=26-422 |
| 9VNF | EM | 2.74 Å | R=25-422 |
| 8FY8 | EM | 2.79 Å | R=26-422 |
| 8FYE | EM | 2.85 Å | R=26-422 |
| 9VMY | EM | 2.86 Å | R=25-422 |
| 8PKM | EM | 2.9 Å | R=1-422 |
| 9DYE | EM | 2.9 Å | R=26-422 |
| 8FYL | EM | 2.94 Å | R=26-422 |
Showing 20 of 29 experimental structures (best resolution first).
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