Hirudin variant-2 is a 72-residue protein from Hirudo medicinalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P09945.
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The mean pLDDT of this model is 83.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4UD9 | X-ray | 1.12 Å | I=61-72 |
| 4UE7 | X-ray | 1.13 Å | I=61-72 |
| 4UDW | X-ray | 1.16 Å | I=62-72 |
| 4UEH | X-ray | 1.16 Å | I=61-72 |
| 5AF9 | X-ray | 1.18 Å | I=61-72 |
| 3RM2 | X-ray | 1.23 Å | I=60-72 |
| 2BVR | X-ray | 1.25 Å | I=61-71 |
| 3SI4 | X-ray | 1.27 Å | I=60-72 |
| 5JZY | X-ray | 1.27 Å | I=61-72 |
| 5MM6 | X-ray | 1.29 Å | I=61-72 |
| 3SV2 | X-ray | 1.3 Å | I=60-72 |
| 6T4A | X-ray | 1.31 Å | I=62-72 |
| 6T56 | X-ray | 1.31 Å | I=62-72 |
| 6T3Q | X-ray | 1.33 Å | I=62-72 |
| 6YB6 | X-ray | 1.33 Å | I=61-72 |
| 6YHG | X-ray | 1.33 Å | I=61-72 |
| 3RM0 | X-ray | 1.34 Å | I=60-72 |
| 6ROT | X-ray | 1.34 Å | A=61-72 |
| 3QX5 | X-ray | 1.35 Å | I=60-72 |
| 6T53 | X-ray | 1.35 Å | I=62-72 |
Showing 20 of 114 experimental structures (best resolution first).
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