Beta-ketoacyl-[acyl-carrier-protein] synthase III (fabH) is a 317-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A6R0.
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The mean pLDDT of this model is 97.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 99% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain (PubMed:10629181, PubMed:7592873, PubMed:8631920, PubMed:8910376). Can also use propionyl-CoA, with lower efficiency (PubMed:10629181, PubMed:8631920)
Homodimer
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8D1U | X-ray | 1.3 Å | A=1-317 |
| 6X7R | X-ray | 1.35 Å | A=1-317 |
| 9KA5 | X-ray | 1.42 Å | A=1-317 |
| 1HNJ | X-ray | 1.46 Å | A=1-317 |
| 9KA6 | X-ray | 1.47 Å | A/B=1-317 |
| 9KA2 | X-ray | 1.5 Å | A/B=1-317 |
| 1HND | X-ray | 1.6 Å | A=1-317 |
| 5BNM | X-ray | 1.7 Å | A/B=1-317 |
| 1EBL | X-ray | 1.8 Å | A/B=1-317 |
| 3IL9 | X-ray | 1.85 Å | A/B=1-317 |
| 5BNR | X-ray | 1.89 Å | A=1-317 |
| 1HNH | X-ray | 1.9 Å | A=1-317 |
| 1HNK | X-ray | 1.9 Å | A=1-317 |
| 1HN9 | X-ray | 2.0 Å | A/B=1-317 |
| 2EFT | X-ray | 2.0 Å | A/B=1-317 |
| 2GYO | X-ray | 2.0 Å | A/B=1-317 |
| 4Z8D | X-ray | 2.0 Å | A/B=1-317 |
| 1MZS | X-ray | 2.1 Å | A=1-317 |
| 5BNS | X-ray | 2.2 Å | A/B=1-317 |
| 9KA7 | X-ray | 2.3 Å | A/B=1-317 |
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