Peptidoglycan-associated lipoprotein (pal) is a 173-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A912.
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The mean pLDDT of this model is 83.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (PubMed:11115123, PubMed:17233825). The Tol-Pal system is also required for polar localization of chemoreceptors clusters (PubMed:24720726). The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity (PubMed:32152098)
The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer (PubMed:17233825). Pal interacts with TolB (PubMed:17375930, PubMed:19696740, PubMed:7744736). Interacts with the C-terminal domain of TolA.…
Cell outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2HQS | X-ray | 1.5 Å | C/E/G/H=65-173 |
| 2W8B | X-ray | 1.86 Å | C/E/G/H=64-173 |
| 1OAP | X-ray | 1.93 Å | A=65-173 |
| 9RLF | EM | 3.17 Å | P=22-173 |
| 9RLE | EM | 3.18 Å | P=22-173 |
| 9RLK | EM | 3.29 Å | P=22-173 |
| 9RLI | EM | 3.63 Å | P=22-173 |
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