3-oxoacyl-[acyl-carrier-protein] synthase 1 (fabB) is a 406-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A953.
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The mean pLDDT of this model is 97.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 99% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860). Can also use unsaturated fatty acids (PubMed:19679654, PubMed:3076377, PubMed:8910376). Catalyzes a key reaction in unsaturated fatty acid (UFA) synthesis, the elongation of the cis-3-decenoyl-ACP produced by FabA (PubMed:19679654). Can use acyl chains from C-6 to C-14 (PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860). Has an absolute requirement for an ACP substrate as the acyl donor, and no activity is detected when both substrates…
Homodimer
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2VBA | X-ray | 1.36 Å | A/B/C/D=1-406 |
| 2VB9 | X-ray | 1.5 Å | A/B/C/D=1-406 |
| 2VB8 | X-ray | 1.52 Å | A/B/C/D=1-406 |
| 6OKC | X-ray | 1.55 Å | A/B=1-406 |
| 2VB7 | X-ray | 1.6 Å | A/B/C/D=1-406 |
| 2BYW | X-ray | 1.7 Å | A/B/C/D=1-406 |
| 7SQI | X-ray | 1.7 Å | A/B=1-405 |
| 1EK4 | X-ray | 1.85 Å | A/B/C/D=1-406 |
| 2BZ4 | X-ray | 1.86 Å | A/B/C/D=1-406 |
| 2BUH | X-ray | 1.9 Å | A/B/C/D=1-406 |
| 8SMS | X-ray | 1.93 Å | A/B=2-405 |
| 2BYZ | X-ray | 1.95 Å | A/B/C/D=1-406 |
| 1H4F | X-ray | 2.0 Å | A/B/C/D=1-406 |
| 2BYX | X-ray | 2.0 Å | A/B/C/D=1-406 |
| 2BZ3 | X-ray | 2.0 Å | A/B/C/D=1-406 |
| 2AQB | X-ray | 2.19 Å | A/B/C/D=1-406 |
| 2BYY | X-ray | 2.2 Å | A/B/C/D=1-406 |
| 7SZ9 | X-ray | 2.2 Å | A/B=2-405 |
| 9MLW | X-ray | 2.21 Å | A/B=2-406 |
| 1FJ8 | X-ray | 2.27 Å | A/B/C/D=1-406 |
Showing 20 of 30 experimental structures (best resolution first).
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