3-oxoacyl-[acyl-carrier-protein] synthase 2 (fabF) is a 413-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0AAI5.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 98.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 99% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Involved in the type II fatty acid elongation cycle (PubMed:6988423, PubMed:9013860). Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:22017312, PubMed:9013860). Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition (PubMed:6988423, PubMed:9013860). Can use acyl chains from C-6 to C-16 (PubMed:22017312, PubMed:9013860). Is able to catalyze the condensation reaction when CoA is the carrier for both substrates (PubMed:22017312)
Homodimer
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3HO9 | X-ray | 1.9 Å | A=2-413 |
| 3I8P | X-ray | 1.9 Å | A=2-413 |
| 3G11 | X-ray | 2.0 Å | A=2-413 |
| 3HO2 | X-ray | 2.0 Å | A=2-413 |
| 7L4E | X-ray | 2.0 Å | A=1-413 |
| 2GFV | X-ray | 2.29 Å | A=2-413 |
| 6OKG | X-ray | 2.3 Å | A=1-413 |
| 6OLT | X-ray | 2.35 Å | A=1-413 |
| 1KAS | X-ray | 2.4 Å | A=2-413 |
| 2GFW | X-ray | 2.4 Å | A=2-413 |
| 2GFX | X-ray | 2.59 Å | A=2-413 |
| 3G0Y | X-ray | 2.6 Å | A=2-413 |
| 1B3N | X-ray | 2.65 Å | A=2-413 |
| 7L4L | X-ray | 2.65 Å | A/B=1-413 |
| 9LPL | X-ray | 2.7 Å | A/B=2-413 |
| 3HNZ | X-ray | 2.75 Å | A=2-413 |
| 2GFY | X-ray | 2.85 Å | A=2-413 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.