Mu-conotoxin KIIIB is a 22-residue protein from Conus kinoshitai. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0C195.
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The mean pLDDT of this model is 63.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 73% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Mu-conotoxin KIIIA-P1: mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.2/SCN2A (IC(50)5-124 nM), Nav1.4/SCN4A (IC(50)=20-90 nM), and Nav1.7/SCN9A (IC(50)=290-413 nM) (PubMed:17724025, PubMed:19221510, PubMed:21652775, PubMed:21709136, PubMed:21781281, PubMed:23146020, PubMed:25658507, PubMed:35167877). It moderately blocks Nav1.1/SCN1A, and mNav1.6/SCN8A (PubMed:17724025, PubMed:21652775, PubMed:21709136, PubMed:21781281, PubMed:23146020, PubMed:25658507, PubMed:35167877). It also shows a very low activity on Nav1.3/SCN3A (PubMed:17724025, PubMed:21781281). This toxin binds a microsite within the pore different from the tetrodotoxin binding site 1…
Monomer
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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