Conorfamide-Tx2 is a 72-residue protein from Conus textile. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0DM27.
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The mean pLDDT of this model is 65.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 69% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
This peptide activates human sensory neuron-specific G protein-coupled receptors MRGPRX1, but not mouse receptors (EC(50)=0.54 uM) (PubMed:30243794, PubMed:37591889). Compared with the agonist chloroquine (anti-malaria drug), it is 600-fold more potent (PubMed:30243794). In vivo, induces itch sensation, since intradermal cheek injection into humanized transgenic mouse (mouse MRGPRX1 replaced by human MRGPRX1) induces scratching (PubMed:30243794). In vivo, treatment of zebrafish larvae with high doses (10 uM) induces hypoactivity at the beginning of the experiment during the dark phase and hyperactivity in the strobe phase after one hour, even after the removal of the toxin from the…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8JGB | EM | 2.84 Å | L=26-43 |
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