Membrane protein (M) is a 222-residue protein from Severe acute respiratory syndrome coronavirus 2. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0DTC5.
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The mean pLDDT of this model is 80.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 56% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by binding cytoplasmic c-terminus of S (PubMed:33229438)
Homomultimer (PubMed:35931673). Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (By similarity). Forms a complex with S proteins (PubMed:33229438). Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (PubMed:35931673). Interacts with the…
Virion membrane, Host Golgi apparatus membrane, Host membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8CME | X-ray | 2.26 Å | C/F/I=176-190 |
| 7VGR | EM | 2.7 Å | A/B=1-222 |
| 7VGS | EM | 2.8 Å | A/B=1-222 |
| 9CTW | EM | 3.01 Å | A/B=1-222 |
| 9CTU | EM | 3.03 Å | A/B=1-222 |
| 8W2E | EM | 3.06 Å | A/B=1-222 |
| 9EXA | EM | 3.2 Å | A/B=17-204 |
| 9BF9 | X-ray | 3.4 Å | G=177-189 |
| 8CTK | EM | 3.52 Å | A/B=1-222 |
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