ORF6 protein (6) is a 61-residue protein from Severe acute respiratory syndrome coronavirus 2. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0DTC6.
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The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Disrupts bidirectional nucleocytoplasmic transport by interacting with the host RAE1-NUP98 complex (PubMed:33360543, PubMed:33849972). Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:32979938). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (By similarity). Prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:33097660). Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation (PubMed:32979938). Might…
Interacts (via C-terminus) with host RAE1 in the NUP98-RAE1 complex (PubMed:35096974); this interaction disrupts the host nuclear import (PubMed:33097660, PubMed:33360543, PubMed:33849972, PubMed:35096974). Interacts with host KPNA2; this interaction may inhibit IFN-beta production by blocking IRF3 nuclear translocation (PubMed:32979938)
Host endoplasmic reticulum membrane, Host Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
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