Thioredoxin (TXN) is a 105-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10599.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 97.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 99% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity…
Homodimer; disulfide-linked (PubMed:17260951, PubMed:9369469). Interacts with TXNIP through the redox-active site (PubMed:17260951). Interacts with MAP3K5 and CASP3 (PubMed:15246877). In case of infection, interacts with S.typhimurium protein slrP (PubMed:19690162). Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (PubMed:9108029)
Nucleus, Cytoplasm, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4OO4 | X-ray | 0.97 Å | A/B=1-105 |
| 3M9J | X-ray | 1.1 Å | A/B=1-105 |
| 2IFQ | X-ray | 1.2 Å | A/B/C=1-105 |
| 2HSH | X-ray | 1.35 Å | A=1-105 |
| 5DQY | X-ray | 1.4 Å | A=1-105 |
| 3M9K | X-ray | 1.5 Å | A/B=1-105 |
| 4OO5 | X-ray | 1.54 Å | A=1-105 |
| 1ERV | X-ray | 1.65 Å | A=1-105 |
| 2HXK | X-ray | 1.65 Å | A/B/C=1-105 |
| 1ERT | X-ray | 1.7 Å | A=1-105 |
| 2IIY | X-ray | 1.7 Å | A=1-105 |
| 3KD0 | X-ray | 1.7 Å | A=1-105 |
| 1ERW | X-ray | 1.8 Å | A=1-105 |
| 4POM | X-ray | 1.85 Å | A/B/C/D=1-105 |
| 1AIU | X-ray | 2.0 Å | A=1-105 |
| 4LL1 | X-ray | 2.0 Å | B/D=1-105 |
| 3E3E | X-ray | 2.01 Å | A/B=1-105 |
| 1AUC | X-ray | 2.1 Å | A=1-105 |
| 1ERU | X-ray | 2.1 Å | A=1-105 |
| 3QFA | X-ray | 2.2 Å | C/D=2-105 |
Showing 20 of 37 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.