Exotoxin A (eta) is a 638-residue protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11439.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis (PubMed:18276581, PubMed:2170123). Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38 (PubMed:21135177)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1IKP | X-ray | 1.45 Å | A=26-638 |
| 1IKQ | X-ray | 1.62 Å | A=26-638 |
| 1XK9 | X-ray | 2.1 Å | A/B=424-638 |
| 1AER | X-ray | 2.3 Å | A/B=425-634 |
| 3B82 | X-ray | 2.35 Å | B/D/F=425-630 |
| 1DMA | X-ray | 2.5 Å | A/B=425-638 |
| 3B78 | X-ray | 2.5 Å | B/D/F=425-630 |
| 3B8H | X-ray | 2.5 Å | B/D/F=425-630 |
| 1ZM9 | X-ray | 2.8 Å | B/D/F=424-630 |
| 1ZM4 | X-ray | 2.9 Å | B/D/F=424-630 |
| 2ZIT | X-ray | 3.0 Å | B/D/F=425-630 |
| 1ZM2 | X-ray | 3.07 Å | B/D/F=424-630 |
| 1ZM3 | X-ray | 3.07 Å | B/D/F=424-630 |
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