P13538: Myosin heavy chain, skeletal muscle, adult

Myosin heavy chain, skeletal muscle, adult is a 1939-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13538.

Organism: Gallus gallus
Length: 1939 residues
Mean pLDDT: 74.6
Model: AF-P13538-F1 v6
Model created: 1 Aug 2025
PDB structures: 15

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Model confidence (pLDDT)

The mean pLDDT of this model is 74.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	11%
70 to 90	Confident: backbone generally right	55%
50 to 70	Low: treat with caution	31%
Below 50	Very low: often disordered regions	4%

What pLDDT means and how to read it

Function

Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)

Subcellular location

Cytoplasm, myofibril

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
2MYS	X-ray	2.8 Å	A=2-844
2W4A	EM	35.0 Å	M=5-844
2W4G	EM	35.0 Å	M=5-844
2W4H	EM	35.0 Å	M=5-844
1M8Q	EM	70.0 Å	A/D/G/P=5-844
1MVW	EM	70.0 Å	A/D/G/J/M/P=5-844
1O18	EM	70.0 Å	A/D/G/J/M/P=5-844
1O19	EM	70.0 Å	A/D/G/J/M/S=5-844
1O1A	EM	70.0 Å	A/D/G/J/M/P=5-844
1O1B	EM	70.0 Å	A/D/G/J=5-844
1O1C	EM	70.0 Å	A/D/G/J/P=5-844
1O1D	EM	70.0 Å	A/D/G/J/M/P=5-844
1O1E	EM	70.0 Å	A/D/G/J/M/P=5-844
1O1F	EM	70.0 Å	A/D/G/J=5-844
1O1G	EM	70.0 Å	A/D/G/J/M/P=5-844

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