cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) is a 921-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14099.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1654333, PubMed:6276403). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity)
Homodimer
Cell membrane, Cytoplasm, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
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