G2/mitotic-specific cyclin-B1 (CCNB1) is a 433-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14635.
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The mean pLDDT of this model is 76.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Essential for the control of the cell cycle at the G2/M (mitosis) transition (PubMed:27030811, PubMed:17495531, PubMed:17495533). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (PubMed:41100585)
Interacts with the CDK1/CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex known as maturation promoting factor (MPF) (PubMed:41100585). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDK1/CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is…
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6GU2 | X-ray | 2.0 Å | B=165-433 |
| 5LQF | X-ray | 2.06 Å | B/E=165-433 |
| 4Y72 | X-ray | 2.3 Å | B=165-433 |
| 5HQ0 | X-ray | 2.3 Å | B=165-433 |
| 9FH9 | EM | 2.5 Å | K/L=1-21 |
| 6GU3 | X-ray | 2.65 Å | B=165-433 |
| 4YC3 | X-ray | 2.7 Å | B=165-433 |
| 6GU4 | X-ray | 2.73 Å | B=165-433 |
| 2B9R | X-ray | 2.9 Å | A/B=165-433 |
| 2JGZ | X-ray | 2.9 Å | B=167-426 |
| 9SKQ | EM | 3.4 Å | B=1-433 |
| 8TAU | EM | 3.5 Å | B=39-50 |
| 7NJ0 | EM | 3.6 Å | C=1-433 |
| 8TAR | EM | 4.0 Å | B=39-50 |
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