Protein translocation protein SEC63 (SEC63) is a 663-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14906.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Acts as a component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination
Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. SEC63 interacts in its phosphorylated form with SEC62. May physically associate with KAR2 in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis. Part of a complex consisting of KAR2, SEC63,…
Endoplasmic reticulum membrane, Nucleus membrane, Nucleus inner membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7KAH | EM | 3.1 Å | D=2-663 |
| 7KAJ | EM | 3.1 Å | D=2-663 |
| 7KAI | EM | 3.2 Å | D=2-663 |
| 6N3Q | EM | 3.68 Å | D=1-663 |
| 7KB5 | EM | 3.8 Å | D=2-663 |
| 7KAS | EM | 3.9 Å | D=2-663 |
| 7KAO | EM | 4.0 Å | D=2-663 |
| 7KAQ | EM | 4.0 Å | D=2-663 |
| 7KAR | EM | 4.0 Å | D=2-663 |
| 7KAU | EM | 4.0 Å | D=2-663 |
| 6ND1 | EM | 4.1 Å | A=1-663 |
| 7KAP | EM | 4.1 Å | D=2-663 |
| 7AFT | EM | 4.4 Å | D=1-663 |
| 7KAT | EM | 4.4 Å | D=2-663 |
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