Potassium voltage-gated channel subfamily B member 1 (Kcnb1) is a 857-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15387.
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The mean pLDDT of this model is 62.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:10024359, PubMed:10618149, PubMed:12451110, PubMed:17379638, PubMed:19276663, PubMed:23878373). Also plays a role in the regulation of exocytosis independently of its electrical function (PubMed:20484665). Forms tetrameric potassium-selective channels…
Homotetramer or heterotetramer with KCNB2 (PubMed:20202934). Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1 (PubMed:8670833, PubMed:8980147, PubMed:9079713, PubMed:9305895, PubMed:9362476, PubMed:9696692). Channel activity is regulated by association with ancillary beta subunits such as AMIGO1,…
Cell membrane, Perikaryon, Cell projection, dendrite, Cell projection, axon, Postsynaptic cell membrane, Synapse, Synapse, synaptosome, Membrane, Lateral cell membrane, Cell membrane, sarcolemma
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2R9R | X-ray | 2.4 Å | B/H=272-304 |
| 4JTA | X-ray | 2.5 Å | B/Q=274-307 |
| 4JTD | X-ray | 2.54 Å | B/H=274-307 |
| 4JTC | X-ray | 2.56 Å | B/H=274-307 |
| 3LNM | X-ray | 2.9 Å | B/D=274-307 |
| 8SD3 | EM | 2.95 Å | A/B/C/D=5-602 |
| 8SDA | EM | 3.32 Å | A/B/C/D=5-602 |
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