Platelet-derived growth factor receptor alpha (PDGFRA) is a 1089-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16234.
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The mean pLDDT of this model is 72.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound…
Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain) (By similarity). Interacts (tyrosine…
Cell membrane, Cell projection, cilium, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GRN | X-ray | 1.77 Å | A=550-973 |
| 8PQJ | X-ray | 1.82 Å | A=550-973 |
| 6A32 | X-ray | 1.87 Å | A=550-973 |
| 6JOL | X-ray | 1.9 Å | A=550-973 |
| 8PQK | X-ray | 2.0 Å | A=550-973 |
| 5K5X | X-ray | 2.17 Å | A=550-973 |
| 1GQ5 | X-ray | 2.2 Å | - |
| 9GZH | X-ray | 2.2 Å | A=550-973 |
| 8PQH | X-ray | 2.5 Å | A=550-973 |
| 6JOJ | X-ray | 2.6 Å | A=550-973 |
| 8PQI | X-ray | 2.6 Å | A=550-973 |
| 7LBF | EM | 2.8 Å | D=1-524 |
| 6JOI | X-ray | 3.1 Å | A=550-973 |
| 7RAM | EM | 3.43 Å | D=1-524 |
| 6JOK | X-ray | 3.8 Å | A=550-973 |
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