Centromere-binding protein 1 (CBF1) is a 351-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P17106.
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The mean pLDDT of this model is 65.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 32% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28
Binds DNA as a dimer. Associates with MET4 to form a heteromeric complex which also includes MET28
Nucleus, Mitochondrion, Chromosome, centromere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SSA | EM | 3.2 Å | K/L=2-351 |
| 8OVW | EM | 3.4 Å | A/B=1-351 |
| 8OW0 | EM | 3.4 Å | A/B=1-351 |
| 8OW1 | EM | 3.7 Å | A/B=1-351 |
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