Gamma-aminobutyric acid receptor subunit gamma-2 (Gabrg2) is a 466-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18508.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2561970, PubMed:30044221). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2561970, PubMed:30044221). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites…
Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties (PubMed:2561970, PubMed:30044221). Interacts with GABARAP (By similarity). Interacts with KIF21B (PubMed:25172774). Identified in a complex…
Postsynaptic cell membrane, Cell membrane, Cell projection, dendrite, Cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2PR9 | X-ray | 2.51 Å | P=400-409 |
| 9OUO | EM | 2.92 Å | D=1-466 |
| 6DW1 | EM | 3.1 Å | D=1-466 |
| 6DW0 | EM | 3.8 Å | D=1-466 |
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