Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit… (PDE6G) is a 87-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18545.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 67% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification
Tetramer composed of two catalytic chains (alpha and beta) and two inhibitory chains (gamma). Interacts with GNAT1; two GNAT1-GTP molecules bind both the catalytic core (PDE6A and PDE6B) and the inhibitory PDE6G subunits, inducing conformational rearrangements that relieve inhibition and activate catalysis
Cell projection, cilium, photoreceptor outer segment
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3JWR | X-ray | 2.99 Å | C/D=70-87 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.