Exendin-3 is a 87-residue protein from Heloderma horridum horridum. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20394.
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The mean pLDDT of this model is 73.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Stimulates vasoactive intestinal peptide (VIP) receptors in high concentrations (>100 nM), resulting in both an increase in cAMP and amylase secretion from pancreatic acini, although at low concentrations (between 0.3 and 3 nM) it increases cAMP without stimulating amylase release. Stimulates the GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9BYO | EM | 2.31 Å | P=48-86 |
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