Beta-adrenergic receptor kinase 1 (GRK2) is a 689-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21146.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:10508278, PubMed:21659505). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:10508278, PubMed:21659505). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to…
Interacts with the heterodimer formed by GNB1 and GNG2 (PubMed:12764189). Interacts with GIT1 (PubMed:9826657). Interacts with, and phosphorylates chemokine-stimulated CCR5 (By similarity). Interacts with ARRB1 (By similarity). Interacts with LPAR1 and LPAR2 (By similarity). Interacts with RALA in response to LPAR1 activation (By similarity). ADRBK1 and RALA mutually inhibit each other's binding…
Cytoplasm, Cell membrane, Cell projection, cilium membrane, Postsynapse, Presynapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3PVU | X-ray | 2.48 Å | A=1-689 |
| 3PVW | X-ray | 2.49 Å | A=1-689 |
| 1OMW | X-ray | 2.5 Å | A=1-689 |
| 5HE0 | X-ray | 2.56 Å | A=30-670 |
| 3PSC | X-ray | 2.67 Å | A=1-689 |
| 5HE3 | X-ray | 2.74 Å | A=30-670 |
| 5HE2 | X-ray | 2.79 Å | A=30-670 |
| 8JPD | EM | 2.81 Å | G=2-689 |
| 5UKM | X-ray | 3.03 Å | A=1-689 |
| 2BCJ | X-ray | 3.06 Å | A=1-689 |
| 8JPB | EM | 3.07 Å | G=2-689 |
| 8JPC | EM | 3.07 Å | G=2-689 |
| 3UZT | X-ray | 3.51 Å | A=1-689 |
| 1YM7 | X-ray | 4.5 Å | A/B/C/D=1-689 |
| 3UZS | X-ray | 4.52 Å | A=1-689 |
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