Guanine nucleotide-binding protein G(q) subunit alpha (Gnaq) is a 359-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P21279.
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The mean pLDDT of this model is 92.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:20966218, PubMed:9687499). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:20966218). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:20966218). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:20966218). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:20966218). Signaling is mediated via…
G proteins are composed of 3 units; alpha, beta and gamma (By similarity). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts (GDP-bound form) with RIC8A (via C-terminus); promoting GNAQ folding and association with the plasma membrane (By similarity). Binds NHERF1 (By similarity). Forms a complex with PECAM1 and BDKRB2 (By similarity). Interacts with GAS2L2…
Cell membrane, Golgi apparatus, Nucleus, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DO9 | X-ray | 2.6 Å | A/C/E=37-350 |
| 7SQ2 | X-ray | 2.6 Å | A=35-359 |
| 4EKD | X-ray | 2.71 Å | A=18-359 |
| 8YFS | EM | 2.8 Å | A=9-359 |
| 3AH8 | X-ray | 2.9 Å | A=37-359 |
| 4QJ3 | X-ray | 3.0 Å | A=7-359 |
| 2BCJ | X-ray | 3.06 Å | Q=37-359 |
| 4QJ4 | X-ray | 3.3 Å | A=7-359 |
| 4QJ5 | X-ray | 3.41 Å | A=7-359 |
| 2RGN | X-ray | 3.5 Å | A/D=37-359 |
| 4GNK | X-ray | 4.0 Å | A/C=7-359 |
| 4EKC | X-ray | 7.4 Å | A/C=18-359 |
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