Acetylcholinesterase (ACHE) is a 614-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22303.
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The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis
Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring…
Synapse, Secreted, Cell membrane, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4M0E | X-ray | 2.0 Å | A/B=33-574 |
| 6NTO | X-ray | 2.05 Å | A/B=33-574 |
| 6O69 | X-ray | 2.08 Å | A=33-574 |
| 5HF5 | X-ray | 2.15 Å | A/B=33-574 |
| 6O5V | X-ray | 2.15 Å | A/B=32-578 |
| 4EY4 | X-ray | 2.16 Å | A/B=33-574 |
| 6WVO | X-ray | 2.19 Å | A/B=33-574 |
| 5HF9 | X-ray | 2.2 Å | A/B=33-574 |
| 5HFA | X-ray | 2.2 Å | A/B=33-574 |
| 8DT7 | X-ray | 2.21 Å | A/B=32-578 |
| 6CQZ | X-ray | 2.22 Å | A/B=33-574 |
| 6NTL | X-ray | 2.25 Å | A/B=33-574 |
| 6U37 | X-ray | 2.25 Å | A/B=32-578 |
| 6WUZ | X-ray | 2.25 Å | A/B=33-574 |
| 6CQT | X-ray | 2.27 Å | A/B=33-574 |
| 6CQW | X-ray | 2.28 Å | A/B=33-574 |
| 6WVQ | X-ray | 2.29 Å | A/B=33-574 |
| 4EY5 | X-ray | 2.3 Å | A/B=33-574 |
| 4M0F | X-ray | 2.3 Å | A/B=33-574 |
| 5FOQ | X-ray | 2.3 Å | A/B=32-576 |
Showing 20 of 79 experimental structures (best resolution first).
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