Ubiquitin-like modifier-activating enzyme 1 (UBA1) is a 1058-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22314.
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The mean pLDDT of this model is 92.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)
Monomer (By similarity). Interacts with GAN (via BTB domain)
Cytoplasm, Mitochondrion, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4P22 | X-ray | 2.75 Å | A/B=1-439 |
| 6DC6 | X-ray | 3.14 Å | A/C=49-1058 |
| 7PYV | X-ray | 3.27 Å | A/B=631-899 |
| 9MC5 | EM | 3.29 Å | A=1-1058 |
| 9MC4 | EM | 3.32 Å | A=1-1058 |
| 9MC6 | EM | 3.32 Å | A=1-1058 |
| 9MC7 | EM | 3.34 Å | A=1-1058 |
| 9MC9 | EM | 3.37 Å | A=1-1058 |
| 9MCB | EM | 3.42 Å | A=1-1058 |
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