Inositol-trisphosphate 3-kinase A (ITPKA) is a 461-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23677.
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The mean pLDDT of this model is 71.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8PP8 | X-ray | 1.59 Å | A/B=188-461 |
| 8PPE | X-ray | 1.59 Å | A/B=188-461 |
| 8PPI | X-ray | 1.65 Å | A/B=188-461 |
| 8PPH | X-ray | 1.7 Å | A/B=188-461 |
| 8PP9 | X-ray | 1.73 Å | A/B=188-461 |
| 8PPA | X-ray | 1.73 Å | A/B=188-461 |
| 8PPG | X-ray | 1.75 Å | A/B=188-461 |
| 8PPJ | X-ray | 1.75 Å | A/B=188-461 |
| 8PPD | X-ray | 1.77 Å | A/B=188-461 |
| 1W2F | X-ray | 1.8 Å | A/B=186-461 |
| 8PPB | X-ray | 1.8 Å | A/B=188-461 |
| 8PPF | X-ray | 1.85 Å | A/B=188-461 |
| 8PPC | X-ray | 1.92 Å | A/B=188-461 |
| 1W2D | X-ray | 1.94 Å | A/B=197-461 |
| 1W2C | X-ray | 1.95 Å | A/B=197-461 |
| 4UPU | X-ray | 2.34 Å | B=158-183 |
| 9QGK | EM | 2.97 Å | A/B/C/D/E=1-461 |
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