Proteinase-activated receptor 1 (F2R) is a 425-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25116.
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The mean pLDDT of this model is 74.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3LU9 | X-ray | 1.8 Å | C/F=33-57 |
| 3BEF | X-ray | 2.2 Å | C/F=49-57 |
| 3HKI | X-ray | 2.2 Å | C/F=42-62 |
| 3VW7 | X-ray | 2.2 Å | A=86-395 |
| 1NRR | X-ray | 2.4 Å | R=43-60 |
| 3HKJ | X-ray | 2.6 Å | C/F=42-62 |
| 9D4Z | EM | 2.74 Å | R=42-425 |
| 1NRP | X-ray | 3.0 Å | R=38-60 |
| 8XOR | EM | 3.0 Å | R=42-397 |
| 1NRN | X-ray | 3.1 Å | R=38-60 |
| 1NRO | X-ray | 3.1 Å | R=38-64 |
| 8XOS | EM | 3.2 Å | R=42-397 |
| 1NRQ | X-ray | 3.5 Å | R=40-60 |
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