Tumor necrosis factor receptor superfamily member 5 (CD40) is a 277-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25942.
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The mean pLDDT of this model is 81.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1LB6 | X-ray | 1.8 Å | B=230-238 |
| 1D00 | X-ray | 2.0 Å | I/J/K/L/M/N/O/P=250-254 |
| 7P3I | X-ray | 2.29 Å | A/C=21-193 |
| 1CZZ | X-ray | 2.7 Å | D/E=250-258 |
| 8YX1 | X-ray | 2.7 Å | C/R=21-193 |
| 5DMJ | X-ray | 2.79 Å | A/D/F=23-193 |
| 8YX9 | X-ray | 2.8 Å | A/D/J/K=21-193 |
| 6PE8 | X-ray | 2.84 Å | T/U=21-193 |
| 6FAX | X-ray | 2.99 Å | R=21-193 |
| 6PE9 | X-ray | 3.13 Å | G/I/J/U/V=21-193 |
| 5IHL | X-ray | 3.3 Å | A/D/F/H=23-193 |
| 1FLL | X-ray | 3.5 Å | X/Y=246-266 |
| 3QD6 | X-ray | 3.5 Å | R/S/T/U=21-190 |
| 5DMI | X-ray | 3.69 Å | A=23-193 |
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