Integrin beta-8 (ITGB8) is a 769-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26012.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity)
Heterodimer of an alpha and a beta subunit (PubMed:1918072). Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8 (PubMed:1918072, PubMed:22278742). ITGAV:ITGB8 interacts with TGFB1 (PubMed:22278742)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6OM1 | X-ray | 2.66 Å | B/D/F/H=43-498 |
| 8VS6 | EM | 2.73 Å | B=43-684 |
| 6OM2 | X-ray | 2.77 Å | B/D=43-463 |
| 9IND | EM | 2.88 Å | B=112-463 |
| 8TCF | EM | 2.9 Å | B=104-467 |
| 8VSD | EM | 3.2 Å | B=114-467 |
| 7Y1T | EM | 3.24 Å | B=43-498 |
| 6UJA | EM | 3.3 Å | B=43-769 |
| 6UJB | EM | 3.51 Å | B=43-769 |
| 6UJC | EM | 3.56 Å | B=43-769 |
| 6DJP | EM | 4.8 Å | B=43-681 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.