Catenin alpha-1 (Ctnna1) is a 906-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26231.
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The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and…
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin (PubMed:16325583). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (By similarity). Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or…
Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell membrane, Cell junction, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1DOW | X-ray | 1.8 Å | A=57-261 |
| 6DV1 | X-ray | 2.2 Å | A/B=652-906 |
| 4E17 | X-ray | 2.3 Å | B=321-356 |
| 4E18 | X-ray | 2.4 Å | B=302-356 |
| 1L7C | X-ray | 2.5 Å | A/B/C=385-651 |
| 5Y04 | X-ray | 2.85 Å | B=276-375 |
| 1DOV | X-ray | 3.0 Å | A=82-262 |
| 9DVA | EM | 3.1 Å | F/H=1-906 |
| 6WVT | EM | 3.56 Å | K/L/N/O/Q/X=671-906 |
| 6O3E | X-ray | 4.0 Å | A/B=82-883 |
| 4K1N | X-ray | 6.5 Å | A/B=1-906 |
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