Chromogranin-A (Chga) is a 463-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26339.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 61.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Strongly inhibits glucose induced insulin release from the pancreas
Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (By similarity). Interacts with SCG3; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2) (PubMed:12388744). Interacts with ITPR1 in the secretory granules (By similarity)
Cytoplasmic vesicle, secretory vesicle, Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DMK | X-ray | 2.45 Å | B/D/F/H=358-371 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.