DNA (cytosine-5)-methyltransferase 1 (DNMT1) is a 1616-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26358.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
DNA methyltransferase that methylates CpG residues (PubMed:17200670, PubMed:18754681, PubMed:21745816, PubMed:26070743). Preferentially methylates hemimethylated DNA (PubMed:21745816, PubMed:26070743). Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance (PubMed:17200670, PubMed:21745816). Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication (PubMed:21745816). It is responsible for maintaining methylation patterns established in development (PubMed:21745816). DNA methylation is coordinated with methylation of histones…
Homodimer (PubMed:19173286). Forms a stable complex with E2F1, BB1 and HDAC1 (PubMed:10888886). Forms a complex with DMAP1 and HDAC2, with direct interaction (PubMed:10888872). Interacts with the PRC2/EED-EZH2 complex (PubMed:16357870). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306). Interacts with UHRF1; promoting its recruitment to…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6X9J | X-ray | 1.79 Å | A=729-1600 |
| 6L1F | X-ray | 1.9 Å | A=140-145 |
| 7SFC | X-ray | 1.97 Å | A=729-1600 |
| 5WVO | X-ray | 2.0 Å | C=351-600 |
| 5YDR | X-ray | 2.0 Å | B=351-599 |
| 7SFF | X-ray | 2.05 Å | A=729-1600 |
| 7SFD | X-ray | 2.09 Å | A=729-1600 |
| 6X9I | X-ray | 2.2 Å | A=729-1600 |
| 7XIB | EM | 2.23 Å | A=351-1616 |
| 6K3A | X-ray | 2.3 Å | B/D/F=161-180 |
| 3EPZ | X-ray | 2.31 Å | A/B=351-600 |
| 7SFG | X-ray | 2.43 Å | A=729-1600 |
| 3SWR | X-ray | 2.49 Å | A=601-1600 |
| 7XI9 | EM | 2.52 Å | A=351-1616 |
| 7SFE | X-ray | 2.55 Å | A=729-1600 |
| 4WXX | X-ray | 2.62 Å | A/B=351-1600 |
| 6X9K | X-ray | 2.65 Å | A=729-1600 |
| 9V36 | EM | 2.77 Å | A=698-1616 |
| 4Z96 | X-ray | 2.85 Å | C=1097-1129 |
| 9V5P | EM | 2.85 Å | A=698-1616 |
Showing 20 of 27 experimental structures (best resolution first).
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