3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A) is a 886-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P27815.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes
Interacts with LYN (via SH3 domain). Interacts with ARRB2
Cytoplasm, perinuclear region, Cell projection, ruffle membrane, Cytoplasm, cytosol, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QYK | X-ray | 2.1 Å | A/B=351-683 |
| 3I8V | X-ray | 2.25 Å | A/B=351-683 |
| 3TVX | X-ray | 2.84 Å | A/B=351-683 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.