Hirudin-2B is a 65-residue protein from Hirudo medicinalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28506.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1OYT | X-ray | 1.67 Å | I=56-65 |
| 1G32 | X-ray | 1.9 Å | C=55-65 |
| 1MU6 | X-ray | 1.99 Å | C=55-65 |
| 1G30 | X-ray | 2.0 Å | C=55-65 |
| 1MU8 | X-ray | 2.0 Å | C=55-65 |
| 1MUE | X-ray | 2.0 Å | C=55-65 |
| 1RIW | X-ray | 2.04 Å | D=55-65 |
| 1KTT | X-ray | 2.1 Å | C=55-65 |
| 1KTS | X-ray | 2.4 Å | C=55-65 |
| 1FPH | X-ray | 2.5 Å | I=54-65 |
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