Hirudin-3A' is a 65-residue protein from Hirudo medicinalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28508.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2CF8 | X-ray | 1.3 Å | I=56-65 |
| 2CF9 | X-ray | 1.79 Å | I=56-65 |
| 4AYY | X-ray | 2.6 Å | D=55-65 |
| 4AZ2 | X-ray | 2.6 Å | D=55-65 |
| 4AYV | X-ray | 2.8 Å | D=55-65 |
| 1DWC | X-ray | 3.0 Å | I=55-65 |
| 1DWD | X-ray | 3.0 Å | I=55-65 |
| 1DWE | X-ray | 3.0 Å | I=55-65 |
| 1DWB | X-ray | 3.16 Å | I=55-65 |
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