Wee1-like protein kinase (WEE1) is a 646-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30291.
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The mean pLDDT of this model is 65.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8BJU | X-ray | 1.53 Å | A=291-575 |
| 9D0S | X-ray | 1.64 Å | A=291-575 |
| 9TG7 | X-ray | 1.68 Å | B=49-60 |
| 1X8B | X-ray | 1.81 Å | A=291-575 |
| 5VD8 | X-ray | 1.85 Å | A=291-575 |
| 5VD9 | X-ray | 1.87 Å | A=291-575 |
| 2IN6 | X-ray | 1.9 Å | A=291-575 |
| 5V5Y | X-ray | 1.9 Å | A=291-575 |
| 5VC5 | X-ray | 1.93 Å | A=291-575 |
| 9D0Q | X-ray | 1.96 Å | A/B=291-575 |
| 5VC3 | X-ray | 1.97 Å | A=291-575 |
| 5VC6 | X-ray | 2.0 Å | A=291-575 |
| 5VD4 | X-ray | 2.02 Å | A=291-575 |
| 5VD2 | X-ray | 2.05 Å | A=291-575 |
| 5VD5 | X-ray | 2.05 Å | A=291-575 |
| 5VD7 | X-ray | 2.08 Å | A=291-575 |
| 5VC4 | X-ray | 2.1 Å | A=291-575 |
| 5VDA | X-ray | 2.1 Å | A=291-575 |
| 2IO6 | X-ray | 2.2 Å | A=291-575 |
| 3BI6 | X-ray | 2.2 Å | A=291-575 |
Showing 20 of 27 experimental structures (best resolution first).
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